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KMID : 1146920230530020333
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Journal of Pharmaceutical Investigation
2023 Volume.53 No. 2 p.333 ~ p.342
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Wound dressing using graphene quantum dots: a proof of concept
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Vanessa Gonzalez Ferreira Caminha Martins
Luciana Magalhaes Rebelo Alencar
Pedro Filho Noronha Souza
Carolinne Margot Albanez Lorentino
Lian Cai
Andre Luis Souza dos Santos
Choi Hye-Rin
Veronica Morandi
Vinicius Goncalves Rodrigues
Jonathas Xavier Pereira
Eduardo Ricci-Junior
Aline Oliveira da Silva de Barros
Ralph Santos-Oliveira
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Abstract
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Purpose : The costs and complexity related to effective wound healing treatment are immense. The number of multifactorial aspects related to the treatment of wounds (inflammation, infection, and many others) implies a complex multi-therapeutic approach involving various procedures, including medication and surgery. Regarding medication, there are only a few options, especially to treat chronic wounds. Recently graphene quantum dots have been applied for their potent antimicrobial properties as well as their significant tissue remodeling properties. In this study, we developed a formulation based on graphene quantum dots in the form of as a dry powder for wound healing.
Methods : Graphene quantum dots were produced by top-down technique using graphite as matrix, and fully characterized by Raman spectroscopy, atomic force microscopy, and X-ray diffractometry. The dry powder formulation was produced under aseptic conditions and evaluated in vitro and in vivo.
Results : The results showed that the formulation improved the healing process in both: in vitro and in vivo, with good adherence, healing time and tissue reconstruction. Finally, the results demonstrated that dry powder was very effective against P. aeruginosa, S. epidermidis, C. albicans and C. tropicalis, representing an improvement for wound healing purposes.
Conclusion : The data corroborated the use of the dry powder formulation using graphene quantum dots as matrix as wound dressing, expanding the use of graphene quantum in the biomedical field.
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KEYWORD
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Inflammation, Healing, Skin, Diabetes, Dry powder, Pharmaceuticals
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